OXIDIZED LIPID COMPOUNDS AND USES THEREOF

摘要

Novel oxidized lipids are provided herein, as well as methods for producing same, and uses thereof in treating or preventing an inflammation associated with endogenous oxidized lipids and related conditions.
wherein
(i) A 1 , A 2 and A 3 are each independently selected from the group consisting of O and S;
(ii) R 1 is an alkyl chain 2-28 carbons in length; and
(iii) R 2 is selected from the group consisting of (3-carboxy)propyl and (2-carboxy)ethyl; and
(iv) R 3 is selected from the group consisting of H, acyl, alkyl, phosphate, phosphocholine, phosphoethanolamine, phosphoethanolamine-N-glutaric acid, and phosphoserine, and phosphoinositol.