发明名称 |
OPHTHALMIC OIL-IN-WATER EMULSIONS CONTAINING CYCLOSPORINE OR A POLYPHENOL |
摘要 |
Disclosed herein are stable oil-in-water emulsion ophthalmic topical liquid compositions having an average particle size less than 1 μm including at least one plant-derived oil other than castor oil wherein the oil comprises only aliphatic side chains free of polar pendent groups. The oil-in-water emulsion ophthalmic topical liquid compositions also include a hydrophilic surfactant having an HLB value between approximately 10 and 14, a vegetable oil-derived hydrophobic non-co-block surfactant having unsaturated side chains that contain less than four oxygen atoms having an HLB value between approximately 4 and 6 and is a liquid at room temperature. The oil-in-water emulsion ophthalmic topical liquid compositions disclosed herein can further include an amount of cyclosporine A effective to relieve dry eye symptoms. |
申请公布号 |
EP2437722(A1) |
申请公布日期 |
2012.04.11 |
申请号 |
EP20100722891 |
申请日期 |
2010.06.02 |
申请人 |
ABBOTT MEDICAL OPTICS INC. |
发明人 |
YU, ZHI-JIAN;HUTH, STANLEY, W.;DEMICHELE, STEPHEN, J. |
分类号 |
A61K9/00;A61K9/107;A61K31/12;A61K36/9066;A61K38/13 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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