发明名称 |
Compositions and their uses directed to IL-4R alpha |
摘要 |
Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation. |
申请公布号 |
US8153603(B2) |
申请公布日期 |
2012.04.10 |
申请号 |
US20060816705 |
申请日期 |
2006.02.24 |
申请人 |
KARRAS JAMES G.;GREGORY SUSAN;CROSBY JEFFREY R.;GUHA MAUSUMEE;TUNG DAVID;FREIER SUSAN M.;ISIS PHARMACEUTICALS, INC. |
发明人 |
KARRAS JAMES G.;GREGORY SUSAN;CROSBY JEFFREY R.;GUHA MAUSUMEE;TUNG DAVID;FREIER SUSAN M. |
分类号 |
A61K48/00;C07H21/04;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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