MELANOMA CELL LINES EXPRESSING SHARED IMMUNODOMINANT MELANOMA ANTIGENS AND METHODS OF USING SAME
摘要
The invention pertains to a method of treating or protecting against melanoma that comprises (a) obtaining a melanoma cell line that expresses one or more shared immunodominant melanoma antigens, (b) modifying the melanoma cell line to render it capable of producing an increased level of a citokyne relative to the unmodified cell line, and (c) administering the melanoma cell line to a mammalian host that has melanoma or is at risk for developing melanoma. Preferably the melanoma cell line is allogenic and is not MHC-matched to the host.
申请公布号
CA2263503(C)
申请公布日期
2012.04.10
申请号
CA19972263503
申请日期
1997.08.04
申请人
THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE;UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
PARDOLL, DREW M.;JAFFEE, ELIZABETH M.;ADLER, ADAM;TOPALIAN, SUZANNE L.;ROSENBERG, STEVEN A.