发明名称 |
Environment-responding siRNA carrier using disulfide-cross-linked polymeric micelle |
摘要 |
Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and siRNA.
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申请公布号 |
US8153110(B2) |
申请公布日期 |
2012.04.10 |
申请号 |
US20070515464 |
申请日期 |
2007.11.22 |
申请人 |
KATAOKA KAZUNORI;NISHIYAMA NOBUHIRO;MATSUMOTO SATORU;THE UNIVERSITY OF TOKYO |
发明人 |
KATAOKA KAZUNORI;NISHIYAMA NOBUHIRO;MATSUMOTO SATORU |
分类号 |
A61K47/48;A61K9/14;C07H21/02 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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