发明名称 |
Polysaccharide-polypeptide conjugate |
摘要 |
Disclosed is a method of producing a polysaccharide-polypeptide conjugate by reacting a polysaccharide with a polypeptide which contains at least one free amino group, wherein a polysaccharide carrier comprising vicinal hydroxyl groups is oxidized under ring opening to create vicinal aldehyde groups and is reacted with one or more base-instable antigenic polypeptide(s) containing at least one free amino group, the polypeptide(s) being bound directly to the polysaccharide carrier via at least one azomethine bond. |
申请公布号 |
US8153135(B2) |
申请公布日期 |
2012.04.10 |
申请号 |
US20050223993 |
申请日期 |
2005.09.13 |
申请人 |
LOIBNER HANS;ECKERT HELMUT |
发明人 |
LOIBNER HANS;ECKERT HELMUT |
分类号 |
A61K39/395;A61K47/48;C07K16/46 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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