摘要 |
The invention relates to a compound of formula 1 (see formula 1) wherein R1 represents hydrogen and R2 represents NR5R6, or R1 represents NR5R6 and R2 represents hydrogen; R3 represents lower alkyl, fluoroalkyl, hydroxyalkyl or carbamoyl; R4 represents hydrogen, lower alkyl or halogen; and R5 and R6 represent, independently of each other, hydrogen, optionally substituted lower alkyl, N-lower alkylpiperidinyl, N-lower alkylpyrrolidinyl, or lower acyl, or R5R6 together represent C4-6 alkylene, oxa-C3-4 alkylene, or aza-C3-4 alkylene wherein the nitrogen atom is unsubstituted or substituted, and wherein alkylene in each case may be partially or totally unsaturated and/or the carbon atoms of alkylene may be substituted; or a N-oxide or a pharmaceutically acceptable salt of such a compound. The compound of formula 1 is useful for the therapy of a disease which responds to an inhibition of protein kinase activity, such as neoplastic disease.
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