发明名称 |
Methods and compositions for inactivating glutamine synthetase gene expression |
摘要 |
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
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申请公布号 |
US8153399(B2) |
申请公布日期 |
2012.04.10 |
申请号 |
US20090589884 |
申请日期 |
2009.10.29 |
申请人 |
LIU PEI-QI;MILLER JEFFREY C.;SANGAMO BIOSCIENCES, INC. |
发明人 |
LIU PEI-QI;MILLER JEFFREY C. |
分类号 |
C12P21/06;C12N1/20;C12Q1/48;C12Q1/68 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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