发明名称 |
Radiolabelled inhibitors of the glycine 1 transporter |
摘要 |
The present invention relates to novel radiolabelled inhibitors of formula I for the Glycine 1 transporter (GlyT1), useful for the labelling and diagnostic imaging of the glycine 1 transporter functionality. wherein R1 is isopropoxy or 2,2,2-trifluoro-1-methyl-ethoxy; and R2 is a radiolabelled group CH3, wherein the radionuclide is 3H or 11C. The radiolabelled compounds of formula I may be used as PET (Positron Emission Tomography) radiotracer for the labelling and diagnostic molecular imaging of the glycine 1 transporter functionality. |
申请公布号 |
US8153679(B2) |
申请公布日期 |
2012.04.10 |
申请号 |
US20090607111 |
申请日期 |
2009.10.28 |
申请人 |
ALBERATI DANIELA;BORRONI EDILIO MAURIZIO;HARTUNG THOMAS;NORCROSS ROGER DAVID;PINARD EMMANUEL;HOFFMANN-LA ROCHE INC. |
发明人 |
ALBERATI DANIELA;BORRONI EDILIO MAURIZIO;HARTUNG THOMAS;NORCROSS ROGER DAVID;PINARD EMMANUEL |
分类号 |
A61K31/4035;C07D209/44;C07D405/04 |
主分类号 |
A61K31/4035 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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