| 摘要 |
PURPOSE: An N-(3-ethinylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolineamine napsylate salt is provided to ensure excellent physico-chemical property and treat hyperproliferative diseases such as cancer in mammal. CONSTITUTION: An N-(3-ethinylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolineamine napsylate salt is denoted by chemical formula 1. The N-(3-ethinylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolineamine napsylate salt is crystalline. The crystal N-(3-ethinylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolineamine napsylate salt is characterized by X-ray diffraction pattern. A method for preparing the N-(3-ethinylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolineamine napsylate salt comprises: a step of dissolving N-(3-ethinylphenyl)6,7-bis(2-methoxyethoxy)4-quinazolineamine in non-polar or polar solvent; a step of dissolving naphthalene-2-sufonic acid in organic solvent and adding to reaction solution; and a step of stirring, filtering, washing, and drying.
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