Fermentative production of lysostaphin antibiotic

摘要

A process for the production of lysostaphin by the fermentation of Staphylococcus staphylolyticus in an aqueous nutrient medium, in which one or both of the following improvements are incorporated in the process: (1) the fermentation is carried out at pH6.5-8.5 in the presence of at least 4% w/w enzymatically hydrolysed casein. (2) the fermentation is carried out at pH 6.4-8.5 in the presence of at least 0.5% of glycerol, mannose or galactose. Antibiotic. Increased yields.