| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a monoclonal antibody or its derivative or fragment, derived from a parent monoclonal antibody and recognizing a Lewis Y antigen. <P>SOLUTION: The human type antibody having an antibody-bi-sected N-acetylglucosamine group has a bi-sected hybrid N-glycosylation pattern in an Fc region or an Fc region equivalent of the monoclonal antibody, or its derivative or fragment, and has an at least 10-fold increased ADCC activity and at least 10%-reduced CDC activity. <P>COPYRIGHT: (C)2012,JPO&INPIT |
