| 发明名称 |
INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING |
| 摘要 |
The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds of general formula (A) wherein A1 is sulfur, A3 is CH, A2 is CH, D is heterocycle, Z is oxygen, SO0-2 or NR, Ar is phenyl and G is not a ring, and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. |
| 申请公布号 |
US2012083482(A1) |
申请公布日期 |
2012.04.05 |
| 申请号 |
US201113314362 |
申请日期 |
2011.12.08 |
| 申请人 |
SAAVEDRA OSCAR MARIO;CLARIDGE STEPHEN WILLIAM;ZHAN LIJIE;RAEPPEL FRANCK;VAISBURG ARKADII;RAEPPEL STEPHANE;MANNION MICHAEL;GAUDETTE FREDERIC;ISAKOVIC LJUBOMIR;GRANGER MARIE-CLAUDE;BERNSTEIN NAOMY;METHYLGENE INC. |
发明人 |
SAAVEDRA OSCAR MARIO;CLARIDGE STEPHEN WILLIAM;ZHAN LIJIE;RAEPPEL FRANCK;VAISBURG ARKADII;RAEPPEL STEPHANE;MANNION MICHAEL;GAUDETTE FREDERIC;ISAKOVIC LJUBOMIR;GRANGER MARIE-CLAUDE;BERNSTEIN NAOMY |
| 分类号 |
A61K31/4365;A61K31/496;A61K31/498;A61K31/5377;A61P35/00 |
主分类号 |
A61K31/4365 |
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