发明名称 |
NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS |
摘要 |
<p num="1">A compound of the following Formula (I) is set forth, including pharmaceutically acceptable salts thereof: wherein Het is a 5 or 6-membered heterocycle with -N, -O, or -S adjacent to the -Ar substituent or adjacent to the point of attachment for the -Ar substituent; Ar is aryl or heteroaryl; R is -CH3, -CH2F, -CHF2 or -CH=CH2; V is -H, -CH3 or =0; W is -NO2, -CI, -Br, -CH2OH, or -CN; X is -CI, -Br, -F, -CH3, -OCH3, or -CN; Y is -CH or -N; and Z is -CH or -N. This compound is useful in compositions for the prevention and treatment of influenza virus.
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申请公布号 |
CA2812935(A1) |
申请公布日期 |
2012.04.05 |
申请号 |
CA20112812935 |
申请日期 |
2011.09.23 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CIANCI, CHRISTOPHER W.;GERRITZ, SAMUEL;KIM, SEAN;LANGLEY, DAVID R.;LI, GUO;PEARCE, BRADLEY C.;PENDRI, ANNAPURNA;SHI, SHUHAO;ZHAI, WEIXU;ZHU, SHIRONG |
分类号 |
C07D403/06;A61K31/496;A61P31/12;A61P31/16;C07D413/06;C07D413/14 |
主分类号 |
C07D403/06 |
代理机构 |
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