发明名称 |
ENRICHMENT OF LOW MOLECULAR WEIGHT DNA |
摘要 |
The present invention provides, among other things, a simple, reproducible, and cost-effective method for enriching fetal or other low molecular weight nucleic acids in a biological sample. In certain embodiments, methods are provided for enriching fetal nucleic acids (e.g., fetal DNAs), typically comprising steps of adding a polymer such as PEG to a heterogeneous biological sample containing fetal DNA and high molecular weight non-fetal DNA such that the PEG precipitates substantially the high molecular weight non-fetal DNA, and purifying the fetal DNA from supernatant, thereby enriching the fetal DNA. |
申请公布号 |
WO2012044581(A1) |
申请公布日期 |
2012.04.05 |
申请号 |
WO2011US53259 |
申请日期 |
2011.09.26 |
申请人 |
ESOTERIX GENETIC LABORATORIES, LLC;OKAMOTO, PATRICIA;GODOSKI, JAN;SCHOLL, THOMAS |
发明人 |
OKAMOTO, PATRICIA;GODOSKI, JAN;SCHOLL, THOMAS |
分类号 |
C07H21/00 |
主分类号 |
C07H21/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|