GENETIC VARIATIONS IN THE INTERLEUKIN-6 RECEPTOR GENE AS PREDICTORS OF THE RESPONSE OF PATIENTS TO TREATMENT WITH INTERLEUKIN-6 RECEPTOR INHIBITORS

摘要

The present invention relates to a method for predicting the response of patients to treatment with Interleukin-6 Receptor (IL6R) inhibitors, such as antibodies directed against the IL6R. The method comprises the analysis of one or more genetic variations in or associated with the Interleukin-6 Receptor gene. The present invention further relates to a kit for use in predicting the response of patients to treatment with IL6R inhibitors, such as Tocilizumab.