The invention provides antibodies which bind to the extracellular domain of the Tyrosine- protein kinase transmembrane receptor ROR1. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of cancer, including non-small cell lung carcinoma, B-cell chronic lymphocytic leukemia and colon cancer.
申请公布号
WO2012045085(A1)
申请公布日期
2012.04.05
申请号
WO2011US54645
申请日期
2011.10.03
申请人
OXFORD BIOTHERAPEUTICS LTD.;ROHLFF, CHRISTIAN;STAMPS, ALASDAIR;TERRETT, JONATHAN, ALEXANDER
发明人
ROHLFF, CHRISTIAN;STAMPS, ALASDAIR;TERRETT, JONATHAN, ALEXANDER