摘要 |
Provided herein are methods, compounds, and compositions for reducing expression of phosphoenolpyruvate carboxykinase-mitochondrial (PEPCK-M) mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for preventing or decreasing diabetes, obesity, metabolic syndrome, diabetic dyslipidemia, and/or hypertriglyceridemia in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of diabetes, obesity, metabolic syndrome, diabetic dyslipidemia, and/or hypertriglyceridemia, or a symptom thereof. |
申请人 |
ISIS PHARMACEUTICALS, INC.;YALE UNIVERSITY;BHANOT, SANJAY;SHULMAN, GERALD |
发明人 |
BHANOT, SANJAY;SHULMAN, GERALD |