PROCESS FOR PURIFYING CYCLIC LIPOPEPTIDE COMPOUNDS OR THE SALTS THEREOF

摘要

A process for purifying cyclic lipopeptide compounds or salts thereof comprises the steps of: (1) charging a crude compound of formula I onto a macroporous adsorption resin; (2) washing the macroporous adsorption resin using water, an organic solvent, or a mixed solution of an organic solvent and water as a washing liquid; and (3) eluting the compound of formula I from the macroporous adsorption resin using water, an organic solvent, or a mixed solution of an organic solvent and water as an eluent. The purification method has the advantages of using a small quantity of organic solvents, using no silica gel, and causing little damage to the environment; the purity of the collected compound of formula I is also improved as compared with the methods previously disclosed.