发明名称 |
LIBRARY-BASED METHODS AND COMPOSITIONS FOR INTRODUCING MOLECULAR SWITCH FUNCTIONALITY INTO PROTEIN AFFINITY REAGENTS |
摘要 |
Methods and compositions are disclosed for introducing molecular switch functionality into a protein affinity reagent to render its binding to a target molecule sensitive to an environmental trigger, such as pH, while maintaining binding affinity to the target molecule. Combinatorial libraries created by the method are also disclosed. |
申请公布号 |
WO2012044831(A1) |
申请公布日期 |
2012.04.05 |
申请号 |
WO2011US54021 |
申请日期 |
2011.09.29 |
申请人 |
BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY;HORN, JAMES, R. |
发明人 |
HORN, JAMES, R. |
分类号 |
C12N15/10 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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