摘要 |
The present invention descrive nanocomplexes also called auto-assembling nanoparticles comprisingbiphosphonates, lipid nanovectors and inorganic nanovectors. In particular the invention describes zoledronic acid complexed with calcium phosphate base nanoparticles; said particles in their turn mixed with lipidic particles e.g. liposomes. Said nanocomplexes are useful, and showed to be be efficient in vivo, as pharmaceutical formulations of biphosphonates for the treatment or prevention of tumor growth and/or metastasis. Tumors can be solidsand/or haematological such as prostate, lung, head/neck, colon, liver, breast, pancreas, kidneys, bladder, male and female urogenital tract, bones, multiple myeloma, primitive and secondary tumours of the central nervous system and lymphomas. |
申请人 |
DE ROSA, GIUSEPPE;CARAGLIA, MICHELE;ISTITUTI FISIOTERAPICI OSPITALIERI;TASSONE, PIERFRANCESCO;LA ROTONDA, MARIA IMMACOLATA;ABBRUZZESE SACCARDI, ALBERTO;SALZANO, GIUSEPPINA;MARRA, MONICA;LEONETTI, CARLO |
发明人 |
DE ROSA, GIUSEPPE;CARAGLIA, MICHELE;TASSONE, PIERFRANCESCO;LA ROTONDA, MARIA IMMACOLATA;ABBRUZZESE SACCARDI, ALBERTO;SALZANO, GIUSEPPINA;MARRA, MONICA;LEONETTI, CARLO |