MANIPULATION OF STEM CELL FUNCTION BY P53 ISOFORMS
摘要
This invention provides methods and compositions for increasing the efficiency of obtaining pluripotent stem cells, the method comprising expressing a 133p53 in cells that are being re-programmed to obtain pluripotent cells. The invention also provides method of inhibiting the proliferation of cancer stem cells, the method comprising suppressing expression of 133p53 in the cells.
申请公布号
CA2812300(A1)
申请公布日期
2012.04.05
申请号
CA20112812300
申请日期
2011.09.30
申请人
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SE CRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
HARRIS, CURTIS C.;HORIKAWA, IZUMI;FUJITA, KAORI;MONDAL, ABDUL M.;PARK, KYE-YOON;PINE, SHARON R.;SERRANO, MANUEL