发明名称 |
PROTEASOME INHIBITORS AND USES THEREOF |
摘要 |
<p>A method of treating a disease in which inhibiting of a proteasome is advantageous is provided. The method comprises administering to the subject a therapeutically effective amount of a compound which binds to a proteasome of a cell, the compound comprising a copper bound to a ligand, the ligand being configured such that upon binding to the proteasome, the copper interacts with cysteine 31 of a Beta2 subunit of the proteasome and further interacts with cysteine 118 of a Beta3 subunit of the proteasome, thereby treating the disease. Additional novel proteasome inhibitors are also provided as well as methods of identifying proteasome inhibitors.</p> |
申请公布号 |
EP2435072(A2) |
申请公布日期 |
2012.04.04 |
申请号 |
EP20100731607 |
申请日期 |
2010.05.26 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
LAVELIN, IRINA;ROTTER, VARDA;OREN, MOSHE;NAVON, AMI;KAM, ZVI;GEIGER, BENJAMIN |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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