发明名称 |
FORMULATION OF FINE PARTICLES USING LIQUEFIED OR DENSE GASES |
摘要 |
<p>The invention provides a method for manipulating or formulating a solid substance which melts under pressure of a gas without degrading at a temperature lower than the melting point of the substance at atmospheric pressure including: applying to the substance a liquefied gas or dense gas to melt the substance without degrading the substance; then contacting the molten substance with a carrier fluid, which is at substantially the same pressure as the liquefied gas or dense gas, to form a solution or mixture of at least a part of the molten substance and the carrier fluid; and passing the solution or mixture into a vessel of lower pressure than the pressure of the liquefied gas or dense gas and carrier fluid to form particles of the substance; and particles formed by the method.</p> |
申请公布号 |
EP1499296(B1) |
申请公布日期 |
2012.04.04 |
申请号 |
EP20030746782 |
申请日期 |
2003.04.15 |
申请人 |
MAP PHARMACEUTICALS INC |
发明人 |
FOSTER, NEIL RUSSELL;REGTOP, HUBERT LEONARDUS;DEHGHANI, FARIBA;TANDYA, ANDRIAN |
分类号 |
A61K9/14;A61K9/00;A61K9/51;A61K31/192;A61K38/13;B01J2/02 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|