发明名称 |
MODULATION OF PHOSPHOLIPASE D FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS |
摘要 |
<p>The present invention relates to methods of treating neurodegenerative diseases comprising administering, to a subject in need of such treatment, one or more agent that inhibits or reduces the action, including the catalytic activity, of an enzyme of the phospholipase D family, such as phospholipase D1 and/or phospholipase D2. The present invention also relates to cell-based assays which may be used to identify agents that inhibit or reduce the activity of enzymes of the phospholipase D family and that may be used in the treatment of neurodegenerative diseases.</p> |
申请公布号 |
EP2435563(A1) |
申请公布日期 |
2012.04.04 |
申请号 |
EP20100781310 |
申请日期 |
2010.05.28 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
DIPAOLO, GILBERT;KIM, TAE-WAN;OLIVEIRA, TIAGO, GIL |
分类号 |
C12N9/99 |
主分类号 |
C12N9/99 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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