| 摘要 |
<p>Pharmaceutical compositions containing as active ingredient a compound of formula Y.NH.CO.Ar where Y is benzhydryl, fluoren-9-yl-dibenzon 2,3;6,7 cycloheptadien-5-yl, xanthen-9-yl; Ar = aryl e.g. phenyl, naphthyl or heterocyclic e.g. pyridyl. The compounds are antirheumatic, antiinflammatory, analgesic, diuretic and sedative agents; 40-70% inhibition of mouse writhing at 50-200 mg/kg. orally, 40% reduction in the carrageenan-induced inflammation of the rat foot by 200 mg/kg. orally of N-(xanthen-9-yl) isonicotinamide; 10 mg/kg. orally of the same compound in the rat gives a 50% incease in urine output without significant loss of potassium. Very low toxicity; no deaths after 2000 mg/kg. orally in mice.</p> |
