| 发明名称 |
Anticuerpos anti-interferón alfa |
| 摘要 |
The present invention relates generally to the generation and characterization of neutralizing anti-IFN-± monoclonal antibodies with broad reactivity against various IFN-± subtypes. The invention further relates to the use of such anti-IFN-± antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-±, in particular, autoimmune disorders such as insulin-dependant diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
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| 申请公布号 |
ES2378062(T3) |
申请公布日期 |
2012.04.04 |
| 申请号 |
ES20020742463T |
申请日期 |
2002.01.29 |
| 申请人 |
GENENTECH, INC. |
发明人 |
CHUNTHARAPAI, ANAN;KIM, JIN;PRESTA, LEONARD;STEWART, TIMOTHY |
| 分类号 |
C12N15/13;G01N33/53;A61K39/395;A61P3/10;A61P5/14;A61P5/50;A61P17/00;A61P37/02;A61P37/06;C07K16/24;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/16;C12N5/20;C12N15/02;C12N15/09;C12P21/02;C12P21/08;G01N33/564;G01N33/577;G01N33/68 |
主分类号 |
C12N15/13 |
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