LCMV-GP-VSV PSEUDOTYPED VECTORS AND TUMOR INFILTRATING VIRUS-PRODUCING CELLS FOR THE THERAPY OF TUMORS

摘要

The invention relates to recombinant VSV viruses and viral vectors which produce a glycoprotein GP of the lymphocyte choriomeningitis virus (LCMV) instead of the G protein of the VSV, to virus producing cells which produce LCMV-GP-pseudotyped VSV virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.