This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
申请公布号
CA2586379(C)
申请公布日期
2012.04.03
申请号
CA20052586379
申请日期
2005.11.14
申请人
BAYER HEALTHCARE LLC
发明人
PAN, CLARK Q.;MURPHY, JOHN E.;MEI, BAISONG;STRAUSS, JONATHAN S.;TJANDRA, HENDRI;CHEN, JIANMIN;BARNETT, THOMAS;TANG, LIANG;WANG, DEQIAN