发明名称 |
Inhibition of interaction of PSD93 and PSDS95 with nNOS and NMDA receptors |
摘要 |
PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC. PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining the MAC of inhalational anesthetics. Suppression of the expression of PSD-95/SAP90 in the spinal cord significantly attenuates responses to painful stimuli mediated through the N-methyl-D-aspartate receptor activation. In spinal cord neurons PSD-95/SAP90 interacts with the N-methyl-D-aspartate receptor subunits 2A/2B. Activation of the N-methyl-D-aspartate receptor in spinal hyperalgesia results in association of the N-methyl-D-aspartate receptor with PSD-95/SAP90. PSD-95/SAP90 is required for hyperalgesia triggered via the N-methyl-D-aspartate receptor at the spinal cord level.
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申请公布号 |
US8148347(B2) |
申请公布日期 |
2012.04.03 |
申请号 |
US201113073238 |
申请日期 |
2011.03.28 |
申请人 |
TAO YUANXIANG;JOHNS ROGER A.;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
TAO YUANXIANG;JOHNS ROGER A. |
分类号 |
C12N15/11;A61K38/00;A61K38/17;A61K45/06;A63B59/06;C07H21/04;C07K14/47 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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地址 |
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