发明名称 |
Bioconjugates as therapeutic agent and synthesis thereof |
摘要 |
The present disclosure relates to a novel enzymatic approach according to the invention using an unprecedented sortase-catalyzed transpeptidation reaction between a substrate comprising LPXTG (SEQ ID NO: 11) peptide motif and biomolecules such as aminosugars, hydroxyamino acids, hydroxyamino acid esters, aminolipids, polyamines; nucleic acids or derivatives thereof; or any molecule having such moieties; or any compound having such moieties to obtain a bioconjugates useful for target delivery of a compound. The present disclosure provides bioconjugates obtained by the novel sortase catalysed transpeptidedation reaction. |
申请公布号 |
US8148321(B2) |
申请公布日期 |
2012.04.03 |
申请号 |
US20080234233 |
申请日期 |
2008.09.19 |
申请人 |
ROY RAJENDRA PRASAD;SAMANTARAY SHARMISHTHA;NATIONAL INSTITUTE OF IMMUNOLOGY |
发明人 |
ROY RAJENDRA PRASAD;SAMANTARAY SHARMISHTHA |
分类号 |
A61K38/00;A01N43/04;A61K31/70 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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