发明名称 |
Compositions and methods for mediating RNAi in vivo |
摘要 |
This invention relates to new formulated lipid particles (FLiPs) comprising at least one of a single or double stranded oligonucleotide, where the oligonucleotide has been conjugated to a lipophile and at least one of an emulsion or liposome to which the conjugated oligonucleotide has been aggregated, admixed or associated. These particles have surprisingly been shown to effectively deliver oligonucleotides to heart, lung and muscle where they effect gene silencing. |
申请公布号 |
US8148344(B2) |
申请公布日期 |
2012.04.03 |
申请号 |
US20090412206 |
申请日期 |
2009.03.26 |
申请人 |
AKINC AKIN;NAKAYAMA TOMOKO;KONYS DAVID;STOFFEL MARKUS;WOLFRUM CHRISTIAN;ALNYLAM PHARMACEUTICALS, INC.;ETH ZURICH |
发明人 |
AKINC AKIN;NAKAYAMA TOMOKO;KONYS DAVID;STOFFEL MARKUS;WOLFRUM CHRISTIAN |
分类号 |
A61K31/70;C07H21/02;C07H21/04;C12Q1/68 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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