N-(pyrazole-3-yl)-benzamide derivatives as glucokinase activators

摘要

Disclosed are the compounds of formula (I) and in particular: 3-Benzyloxy-5-isopropoxy-N-(1-pyridine-2-ylmethyl-1H-pyrazol-3-yl)-benzamide, 3-Benzyloxy-5-isopropoxy-N-(5-methyl-1-pyridine-2-ylmethyl-1 H-pyrazole-3-yl)-benzamide, 3-Benzyloxy-N-(1-benzyl-1H-pyrazol-3-yl)-5-isopropoxy-benzamide, N-(1-Benzyl-1H-pyrazole-3-yl)-3-((S)-2-methoxy-1-methyl-ethoxy)-5-( (S)-1-methyl-2-phenyl-ethoxy)-benzamide, 3-((S)-2-Methoxy-1-methyl-ethoxy)-5-((S)-1-methyl-2-phenyl-ethoxy)-N-(1-pyridine-2-ylmethyl-1 H-pyrazole-3-yl)-benzamide, 3-lsopropoxy-N-(1-pyridine-2-ylmethyl-1H-pyrazole-3-yl)-5-(2-thiophene-3-yl-ethoxy)-benzamide, 3-((S)-2-Methoxy-1-methyl-ethoxy)-5-((S)-1-methyl-2-phenyl-ethoxy)-N-(1-pyridine-3-ylmethyl-1H-pyrazole-3-yl)-benzamide, 3-((S)-2-Methoxy-1-methyl-ethoxy)-5-((S)-1-methyl-2-phenyl-ethoxy)-N-(1-pyridine-4-ylmethyl-1H-pyrazole-3-yl)-benzamide, N-(1-Benzyl-1H-pyrazol-3-yl)-3-isopropoxy-5-(2-thiophen-3-yl-ethoxy)-benzamide, and 3-(4-methanesulfonyl-phenoxy)-5-((S)-2-methoxy-1-methyl-ethoxy)-N-(1-pyridin-3-ylmethyl-1H-pyrazol-3-yl)-benzamide and methods for their synthesis and medicaments thereof for treating insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus, obesity, neuropathy and/or nephropathy.