METHOD AND GENE STRUCTURE FOR HIGH SPECIFIC INHIBITING OF UNWANTED CELL GROWTH

摘要

The present invention relates to molecular biology and gene therapy of diseases at which an unwanted cell proliferation happens. The present invention relates to a gene structure comprising 3'-untranslated region of the gene transcript selected from the gene DNA-topoisomerase II alpha (TOP2A) of a human and the gene DNA-(cytosin-5)-methyltransferase 1 (DNMT1) of a human; kDNA at least one protein inhibiting cell growth; and a promoter, transcriptional activity of which is specific for target cells. Excessively proliferating neoplastic or nonneoplastic cells serve as the target cells for administering said structure. The present invention also relates to a method for increasing specificity of inhibiting and to a method of properly inhibiting of unwanted growth of target cells by administering therein said gene structure.