Anti-FGF19 antibodies and methods using same

摘要

Disclosed are anti-FGF19 antibodies, and compositions comprising and methods of using these antibodies, methods using anti-FGF19 antibodies, and methods comprising detection of FGF19 and/or FGFR4. The anti-FGF19 antibody comprising: (a) a light chain comprising (i) HVR (hypervariable region)-L1 comprising sequence KASQDINSFLS (SEQ ID NO: 1); (ii) HVR-L2 comprising sequence RANRLVD (amino acids 50-56 of SEQ ID NO:4); and (iii) HVR-L3 comprising sequence LQYDEFPLT (SEQ ID NO:3); and (b) a heavy chain comprising (i) HVR-H1 comprising sequence TYGVH (SEQ ID NO:5); (ii) HVR-H2 comprising sequence VIWPGGGTDYNAAFIS (SEQ ID NO:6); and (iii) HVR-H3 comprising sequence KEYANLYAMDY (SEQ ID NO:7).