PHARMACEUTICAL COMPOSITION, COMPRISING AN ANTI-CD6 MONOCLONAL ANTIBODY USED IN THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS

摘要

Disclosed is a hybridoma having the deposit No. ECACC 96112640, or a progenitor cell thereof capable of producing a monoclonal antibody that recognizes the human leukocyte differentiation antigen C06 but does not inhibit the binding of CD6 to its ligand ALCAM. Further disclosed is the use of a monoclonal antibody that recognizes the human leukocyte differentiation antigen CD6 but does not inhibit the binding of CD6 to its ligand ALCAM and an appropriate excipient, wherein said antibody is the humanized antibody T1h, produced by the secreting hybridoma IOR-T1A with deposit No. ECACC 96112640 for the manufacture of a medicament for the treatment of Rheumatoid Arthritis.