| 发明名称 |
GENETICALLY ENGINEERED BLEB VACCINE |
| 摘要 |
The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention have one or more genetic changes in the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS. |
| 申请公布号 |
PL211017(B1) |
申请公布日期 |
2012.03.30 |
| 申请号 |
PL20000353891 |
申请日期 |
2000.07.31 |
| 申请人 |
SMITHKLINE BEECHAM BIOLOGICALS S.A. |
发明人 |
BERTHET FRANCOIS-XAVIER JACQUES;DALEMANS WILFRIED L.J.;DENOEL PHILIPPE;DEQUESNE GUY;FERON CHRISTIANE;LOBET YVES;POOLMAN JAN;THIRY GEORGES;THONNARD JOELLE;VOET PIERRE |
| 分类号 |
C12N15/09;C12N15/74;A61K39/00;A61K39/02;A61K39/04;A61K39/09;A61K39/095;A61K39/102;A61K39/12;A61K39/145;A61P27/16;A61P29/00;A61P31/04;A61P31/12;A61P31/16;C07K14/195;C07K14/21;C07K14/22;C07K14/285;C12N1/21;C12N15/31;C12R1/36 |
主分类号 |
C12N15/09 |
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