| 摘要 |
Disclosed is a process for manufacturing at least one macrocyclic compound; said process comprises the steps of: (a) providing a reaction system comprising one or more reactants in a reaction medium, wherein said reactants are capable of forming the macrocyclic compound in said reaction medium at a first set of reaction conditions through at least one desired reaction pathway that includes at least cyclization reaction(s), and wherein said reactants are further capable of forming undesired oligomers at said first set of reaction conditions through at least one undesired reaction pathway that includes undesired oligomerization reactions, and (b) modulating oligomerisation reactions in the reaction medium, so as to reduce formation of the undesired oligomers by said one or more reactants and/or to reduce separation of the undesired oligomers from said reaction medium, relative to corresponding unmodulated oligomerization reactions, wherein modulation of the oligomerization reactions includes adding one or more oligomerization control additives comprising one or more extraneous oligomerization byproducts into the reaction medium.
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