| 发明名称 |
CYCLIC PEPTIDE CXCR4 ANTAGONISTS |
| 摘要 |
A lactam-cyclized peptide of formula (I) where R1, X1, X3, X7-X10 and R2 are as defined in the claims. The peptide is cyclized by an amide bond between the side chains of the residues X1 and X7. The peptide is a CXCR4 antagonist and can be used for the treatment of cancers, rheumatoid arthritis, pulmonary fibrosis and HIV infection.
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| 申请公布号 |
NZ580849(A) |
申请公布日期 |
2012.03.30 |
| 申请号 |
NZ20080580849 |
申请日期 |
2008.05.20 |
| 申请人 |
ELI LILLY & COMPANY - LILLY CORPORATE CENTRE,INDIANAPOLIS,INDIANA, |
发明人 |
KOHN, WAYNE DAVID;PENG, SHENG-BIN;YAN, LIANG ZENG |
| 分类号 |
A61P31/18;A61K38/12;C07K7/54 |
主分类号 |
A61P31/18 |
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