5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS

摘要

Disclosed is a compound of the formula I or a pharmaceutically acceptable salt or hydrate thereof, e.g. 1-(4-Amino-5-fluoropyrimidin-2-yl)-N-((1-(pyridin-3-yl)cyclohexyl)methyl)-3- (trifluoromethyl)-1H-pyrazole-4-carboxamide wherein Z represents pyrazole, thiazole, imidazole, oxazole or thiophene and the other substituents are defined in the specification for treating pain, osteoarthritis, rheumatoid arthritis, arthrosclerosis, glaucoma, irritable bowel syndrome, inflammatory bowel disease, cirrhosis, lupus, scleroderma, Alzheimer's disease, traumatic brain injury, asthma, chronic obstructive pulmonary disease, or interstitial fibrosis.