| 摘要 |
Disclosed is an intravaginal delivery system for the controlled release of therapeutically active substances or prodrugs thereof over a prolonged period of time, the system comprising at least one compartment, said one or each 5 compartment comprising a core and a membrane encasing the core, said core and membrane comprising a same or different polymer composition, wherein at least one compartment comprises drospirenone and at least one compartment, which may be the same or different from the one comprising drospirenone, comprises an estrogen, and wherein the polymer composition comprises poly(dimethylsiloxane) based elastomer which comprises poly(alkylene oxide) groups.
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