发明名称 |
POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES |
摘要 |
Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products. |
申请公布号 |
US2012076817(A1) |
申请公布日期 |
2012.03.29 |
申请号 |
US201113243480 |
申请日期 |
2011.09.23 |
申请人 |
HUMAN SERVICES;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND |
发明人 |
LEE CHE-HUNG ROBERT;FRASCH CARL E. |
分类号 |
A61K39/385;A61P31/04;A61P37/04 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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