发明名称 |
RECOMBINANT FUSION PROTEIN AND POLYNUCLEOTIDE CONSTRUCT FOR IMMUNOTOXIN PRODUCTION |
摘要 |
The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
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申请公布号 |
US2012076780(A1) |
申请公布日期 |
2012.03.29 |
申请号 |
US201113239847 |
申请日期 |
2011.09.22 |
申请人 |
BARNEA ITAY;BENHAR ITAI;BEN-YOSEF RAHAMIM;VEXLER AKIVA |
发明人 |
BARNEA ITAY;BENHAR ITAI;BEN-YOSEF RAHAMIM;VEXLER AKIVA |
分类号 |
A61K39/395;A61P35/00;C07K19/00;C12N5/09 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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