发明名称 |
COMPOSITIONS AND METHODS FOR PREDICTING HCV SUSCEPTIBILITY TO ANTIVIRAL AGENTS |
摘要 |
Methods for determining the susceptibility of a hepatitis C virus (HCV) in a patient to anti-viral agents, particularly cyclophilin inhibitors such as cyclosporine A, are disclosed. The methods include determining the amino acid sequence within a region of the HCV NS5A protein and comparing the viral amino acid sequence to that of a reference strain, wherein the existence of at least one variant/mutation in the viral genome is indicative that the virus is more or less susceptible to anti-viral agents. Also disclosed are isolated polynucleotide molecules, replicons, and kits that can be used to assay the susceptibility of hepatitis HCV in a patient to anti-viral agents. |
申请公布号 |
WO2012039964(A1) |
申请公布日期 |
2012.03.29 |
申请号 |
WO2011US51068 |
申请日期 |
2011.09.09 |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;ANSARI, ISRAR;STRIKER, ROBERT |
发明人 |
ANSARI, ISRAR;STRIKER, ROBERT |
分类号 |
C12Q1/70 |
主分类号 |
C12Q1/70 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|