Pleuromutilin derivatives for the treatment of diseases mediated by microbes

摘要

A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R are in vicinal position (if m = 0 then R is in position 2', and if m = 1 then R is on position 1'); R is ethyl or vinyl; R is hydrogen or (C)alkyl; R is hydrogen or - (C)cycloalkyl, or - unsubstituted (C)alkyl, or - (C)alkyl substituted by one or more of - hydroxy; preferably one or two, - methoxy, - halogen, - (C)cycloalkyl, or Rand R together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e. g. selected from N or O, or R is hydroxy and R is formyl; R is OH, OR, a halogen atom, or - with the proviso that R is bound to 2' R represents -O-(CH)-O- with p is 2 or 3; R is unsubstituted (C)alkyl or (C)cycloalkyl.