摘要 |
The present invention relates to activatable toxin complexes which include a cleavable inhibitory peptide. More specifically, the complexes comprise a cell targeting domain, a toxin catalytic domain, a specific protease cleavage site and an inhibitory peptide domain. The inhibitory peptide prevents the catalytic domain from exerting toxic effects until its release from the complex by the action of a protease, such a viral protease, at the protease cleavage site. Further provided are pharmaceutical compositions comprising the complexes and use thereof for treating infections and malignant disease. |
申请人 |
RAMOT AT TEL-AVIV UNIVERSITY LTD.;BENHAR, ITAI;SHAPIRA, ASSAF;GAL-TANAMY, MEITAL;GREENFELD, DANA;NAHARY, LIMOR;ZEMEL, ROMY;TUR-KASPA, RAN |
发明人 |
BENHAR, ITAI;SHAPIRA, ASSAF;GAL-TANAMY, MEITAL;GREENFELD, DANA;NAHARY, LIMOR;ZEMEL, ROMY;TUR-KASPA, RAN |