发明名称 |
Targeted Lung Delivery of Citrulline and/or Another Nitric Oxide Precursor and a Method for Treatment of Pulmonary Deficiency of Nitric Oxide in Cystic Fibrosis and Other Pulmonary Diseases |
摘要 |
A method of treatment of cystic fibrosis and other pulmonary diseases identified by nitric oxide deficiency, comprising administration of a nebulized solution of citrulline and/or another nitric oxide precursor as an inhalable aerosol or an inhalable dry powder for targeted delivery into conducting and central airways. Citrulline or another nitric oxide precursor is formulated as a composition having predetermined limited volume, salinity, pH and osmolality. The composition is nebulized into an aerosol having a mass median aerodynamic diameter (MMAD) between 2 μm and 6 μm. |
申请公布号 |
US2012076859(A1) |
申请公布日期 |
2012.03.29 |
申请号 |
US20100888729 |
申请日期 |
2010.09.23 |
申请人 |
HOFMANN THOMAS;ACTIVAERO GMBH |
发明人 |
HOFMANN THOMAS |
分类号 |
A61K31/197;A61K9/14;A61P11/00;C07C275/16 |
主分类号 |
A61K31/197 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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