发明名称 |
5a-ANDROSTANE (ALKYL)-3ß,5,6ß-TRIOL INJECTION AND PREPARATION METHOD THEREFOR |
摘要 |
A 5a-androstane (alkyl)-3ß,5,6ß-triol injection and preparation method therefor, the injection whereof using hydroxypropyl-ß-cyclodextrin as a solubilizer and the active ingredient whereof being present preferably in a proportion by weight of 1-20:40-500 to the cyclodextrin. The injection may also comprise 1-100 parts of an isotonic regulator, 0-200 parts of a lyophilized filler, 0-2000 parts of a solvent. The preparation method comprises separately and successively dissolving the hydroxypropyl-ß-cyclodextrin solution, the active ingredient and other soluble accessory ingredients in the water for injection, then after decolorization, depyrogenation, filtering, and sterilization of the filtrate, a liquid injection solution is obtained. Drying the filtrate yields a solid for injection. |
申请公布号 |
WO2012037834(A1) |
申请公布日期 |
2012.03.29 |
申请号 |
WO2011CN76968 |
申请日期 |
2011.07.08 |
申请人 |
SUN YAT-SEN UNIVERSITY;YAN, GUANGMEI;HU, HAIYAN;ZHANG, JINGXIA;QIU, PENGXIN;LI, LING;TIAN, NING |
发明人 |
YAN, GUANGMEI;HU, HAIYAN;ZHANG, JINGXIA;QIU, PENGXIN;LI, LING;TIAN, NING |
分类号 |
A61K31/565;A61K9/08;A61K9/14;A61K9/19;A61K47/40;A61P9/00;A61P25/00 |
主分类号 |
A61K31/565 |
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