发明名称 |
USE OF DYNAMIN RING STABILIZERS |
摘要 |
<p>There is provided a method for promoting dynamin ring formation and/or maintenance of dynamin rings in a cell, comprising treating the cell with an effective amount of a dynamin ring stabilizer, or a prodrug or pharmaceutically acceptable salt of the dynamin ring stabilizer. The maintenance or accumulation of dynamin ring formation has particular application in the prophylaxis or treatment of a kidney disease or condition characterized by proteinuria. A dynamin ring stabilizer can be any agent that interacts with dynamin to promote dynamin ring assembly and/or inhibit dynamin ring disassembly. There are also provided methods for prophylaxis or treatment of podocyte dysfunction and/or maintaining or inducing actin cytoskeleton formation in a cell utilizing dynamin ring stabilizers, and for screening a test agent for use as a dynamin ring stabilizer.</p> |
申请公布号 |
EP2432465(A1) |
申请公布日期 |
2012.03.28 |
申请号 |
EP20100777248 |
申请日期 |
2010.05.21 |
申请人 |
CHILDREN'S MEDICAL RESEARCH INSTITUTE;THE GENERAL HOSPITAL CORPORATION |
发明人 |
ROBINSON, PHILLIP J.;SEVER, SANJA |
分类号 |
A61K31/275;A61K31/352;A61K31/404;A61P13/12 |
主分类号 |
A61K31/275 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|