PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR METABOLIC SYNDROME

摘要

Disclosed are: a method for screening a substance for treating metabolic syndrome that develops visceral obesity and abnormal lipid metabolism; and a composition for preventing and/or treating the syndrome. The screening method comprises: (1) an extraction step of extracting a total RNA fraction from a skeletal muscle collected from each of non-human mammals that constitute a test substance-administered group to which a predetermined amount of the test substance has been administered for a predetermined period and each of non-human mammals that constitute a test substance-unadministered group to which the test substance has not been administered; (2) a quantification step of quantifying the expression quantity of mRNA contained in the total RNA fraction extracted in the extraction step and encoding a sugar transporter gene by a specific method; and (3) a step of comparing and analyzing the quantity of the test substance ingested, the body weight gain, and the expression quantity of RNA encoding the sugar transporter gene during the predetermined period between the non-human mammals that constitute the test substance-administered group and the non-human mammals that constitute the test substance-unadministered group to thereby determine the effect of the test substance on the metabolic syndrome.